Challenge
The client was undergoing a major shift in their analytical pipeline: ADC‑related pipelines were projected to dominate the portfolio in the coming years, while existing manual workflows were already at their operational limit. The main bottleneck was the manual sample preparation cycle, which consumed significant operator time and introduced variability across analyses.
The client needed a future‑proof, modular automation strategy capable of starting with sample preparation and gradually expanding analytical coverage, all while remaining compliant with internal risk evaluation procedures and maintaining appropriate containment performance.
Solution
NEVESO performed a comprehensive Business Case and Technical Feasibility assessment, combining EHS risk modelling, building readiness analysis, vendor evaluation, and automation architecture design.
The work began with a detailed application of internal standards aligned with industry guidelines, resulting in a requirement for a baseline containment level with the option to escalate under specific high‑potency handling conditions. Based on this, NEVESO designed a dedicated ADC containment room in collaboration with the client’s EHS department.
In parallel, NEVESO evaluated multiple automation scenarios, quantifying integration costs, software implications, operational impact, and ROI timelines. The analysis identified a modular roadmap beginning with the automation of sample preparation, and sequential expansion toward broader analytical coverage. The recommended approach balanced safety, cost, usability, and long‑term scalability.
Business Impact
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Clear automation strategy grounded in EHS, ROI, and operational constraints
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Compliance with baseline containment requirements, with escalation paths for high‑potency compounds
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Quantified annual savings in the mid six‑figure range from sample‑prep automation, with additional gains when expanding to partial end‑to‑end analysis
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A scalable blueprint aligned with a forecasted increase in ADC‑related work
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Reduced operator exposure and safer workflows through minimized manual touchpoints
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Modular expansion path from sample preparation to full molecular characterization
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Minimal disruption to existing IT and scheduling frameworks thanks to reuse of already adopted software
